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The increase in ROS levels activates the transcriptional factor NF-κB, leading transactivation of the viral genes and inducing the transcription of viral proteins [12]

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Overexpressing FoxO3 in CamKII-positive cells of the forebrain and in neuroblasts and neurons of the dentate gyrus by a conditional tetracycline-off transgenic mouse ( FoxO3 transgenic mice, the authors identified Pik3ip1 as a target gene of FoxO3, which can enhance pre-existing pro-apoptotic stimuli