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Sermorelin’s engagement of GHRHR activates adenylate cyclase through Gs coupling , elevating intracellular cAMP, activating PKA, phosphorylating CREB and other transcription factors driving GH gene expression, and triggering the calcium-dependent exocytosis cascade releasing GH granules from somatotroph secretory vesicles

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doi: 10.1134/S0006297921010089 [DOI] [PubMed] [Google Scholar] 131.Netto LES, Antunes F