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Hyaluronic acid plays a practical role because it supports hydration and a plumper look, which can immediately improve the appearance of dryness-driven creasing while peptides support longer-term renewal

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Accordingly, the expression changes of L2HGDH by sg L2HGDH , L2HG treatment, or L2HGDH OPT led to decreased or increased DNA hydroxymethylation in the CBS promoter CpG island (Fig