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Factors such as matrix interactions and chemical structures influence the bioaccessibility of phytochemicals, whereas bioavailability can be affected by multiple parameters, such as biological membranes (GI wall), the physicochemical properties of the phytochemicals, biological environment inside the GI, etc., The optimum properties of phytochemicals/drugs for GI absorption have been defined by Lipinski’s Rule [156], including appropriate molecular weight, hydrogen bonding capability, and partition coefficient (LogP) [156]

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