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The DOR was the first of the opioid receptors where a peptide antagonist, [ N , N ′-diallyl-Try 1 .Aib 2,3 ,Leu 5 ]enkephalin (ICI174864), was found to decrease signaling even in the absence of agonist (Costa and Herz, 1989)

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AOD-9604's lipolytic activity is suppressed by insulin, so fasted administration is essential