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The standard body surface area scaling method, endorsed by the FDA for first-in-human dose estimates, typically divides the rodent dose by a factor of approximately 6.2 when converting from rat to human

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The model automatically updates the weight every 24 h, can predict the training effect 3–5 days in advance (with an accuracy of 75%–85%), and gives optimization suggestions, such as “adding 1 day of recovery period” or “adjusting the altitude by 300 m”