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They can bind to free fatty acid receptors (FFARs) on immune cells, while butyrate, as a HDAC inhibitor, can upregulate the expression of anti-inflammatory genes and induce microglial polarization toward an anti-inflammatory phenotype (Zhao et al., 2022

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Indeed, PS-mediated uptake of erythrocytes promoted phenotype changes in monocyte-derived macrophages, contributing to recovery from experimental intracerebral hemorrhage