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Mercuric chloride resulted in upregulation of GSH levels, and normal levels of GSH efflux were diminished in the presence of mercury, while HgCl 2 inhibited transport of the substrate calcein acetoxymethylester by both human MRP1 and MRP2 in MDCKII cells, suggesting that the Hg–GSH complex is exported through MRP1 and MRP2
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This release acts as a biological signal that triggers repair and remodelling cascades
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