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Acetyl-l-carnitine deficiency in patients with major depressive disorder | PNAS

Carnitine O -acetyltransferase Carnitine O -acetyltransferase (CrAT), located primarily in the mitochondrial matrix, catalyzes the addition or the removal of carnitine from medium- and short-chain acyl-CoA 60,61 , facilitating the efflux of mitochondrial acetyl-CoA to the cytosol and buffering the intracellular pools of acetyl-CoA and carnitine

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This may explain why some users report darker freckles, more visible sun spots or greater contrast between different areas of the skin after starting Melanotan 2