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2022 found severe gastrointestinal adverse events (AEs) related to semaglutide treatment were reported in 1,778 GI cases and 3,601 overall cases, resulting in 40 (2.25%) and 102 (2.83%) deaths, respectively [51]
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Also, my digestion was totally wrecked after the mega-supplement poisoning episode (despite trying all sorts of fancy probiotics at the same time under the guidance of nutritionists)