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Moreover, we believe the management of COPD as a chronic disease should be shifted from symptomatic reactive pharmaceutical intervention to more constructive and non-toxic approaches using a single or combination of natural and nutritional agents with potential muscle metabolic enhancing and immunomodulating activities to achieve a better overall outcome for the patients in terms of morbidity, mortality, and medical cost-reduction
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Studies in melanocyte cell lines and receptor-transfected systems have characterised the cAMP signalling response, tyrosinase induction, and melanin output associated with MT-1 receptor engagement
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