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Hadigan et al

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Elevated homocysteine bypasses the normal regulatory mechanism by acting as a direct NMDA receptor agonist.⁵ This means that homocysteine can activate NMDA receptors and trigger calcium influx even when normal magnesium levels are present.⁶ People with MTHFR C677T variants and inadequate B-vitamin intake often carry chronically elevated homocysteine, meaning their NMDA receptors are partially activated before a single Wi-Fi packet is transmitted