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First characterized in the early 1990s, it has since accumulated a large body of preclinical (animal) research on soft-tissue and gastrointestinal healing (Sikiric et al., Current Pharmaceutical Design , 2018)

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Additional mechanistic studies demonstrated that both dihexa and Nle 1 -AngIV, its parent compound, were effective stimulators of hippocampal synaptogenesis, thus providing a rational explanation for their procognitive activities