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Reviewing the team's patent and related documents at Talpos's request, Anna Mapp, the Edwin Vedejs Collegiate Professor of Chemistry at the University of Michigan, and also the President of the American Peptide Society, questioned the limited detail available and the absence of a published sequence for the peptide's parent protein, an omission she noted makes the original work impossible to reproduce

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Precursors that the body converts into NAD+, mainly nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), reliably raise NAD+ levels in the blood and are generally well tolerated