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In cytokine-stimulated astrocytes, arginine deprivation activates the amino acid-sensing kinase GCN2, leading to phosphorylation of eukaryotic initiation factor 2α (eIF2α) and suppression of iNOS protein synthesis, thereby attenuating NO production

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Excessive ROS generation and oxidative stress exacerbate pancreatic cell injury, promote inflammatory responses, and ultimately lead to extensive pancreatic tissue damage and functional failure (117)