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However, this pathway is reported to be inactive in most tissues, and in the few tissues in which it is active, its function is reduced in tumours from the corresponding tissue 16

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Uniquely for nasal sprays, the stability testing program must include device performance tests — spray content uniformity (SAC) and droplet size distribution (DSD) — at stability time points alongside the standard formulation tests (assay, impurities, pH, appearance, viscosity)