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Cryo-EM structures published in Cell Discovery in 2024, showing retatrutide bound to all three receptors, describe it as developed from the GIP backbone — a different starting point from tirzepatide's design logic — and place the acylation on the lysine at position 17 of the peptide (DOI)

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pylori infection induces chronic inflammation of the stomach, which may progress to peptic ulcer disease, atrophic gastritis, and/or gastric cancer in some individuals