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A 2025 review and patent analysis in Pharmaceuticals raised concerns specifically about the compound's pro-angiogenic and nitric-oxide-related activity

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The dissociation/relaxation of nCRP into nnCRP occurs on necrotic, apoptotic, and ischemic cells, membranes of activated platelets, monocytes, and endothelial cells, and on the surface of microparticles, via phosphorylcholine binding and seems to be, as mCRP, proinflammatory (194–196)