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Investigating Individual Differences in Immune Response to Gene Therapy A study of 125 healthy adult blood donors from the United States, with a median age of 43 years, found pre-existing nAbs against SaCas9 (Staphylococcus aureus Cas9) and SpCas9 (Streptococcus pyogenes Cas9) in 78% and 58% of samples, respectively

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