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Inhibition of heat-shock protein 90 enhances the susceptibility to antifungals and reduces the virulence of Cryptococcus neoformans/Cryptococcus gattii species complex
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Its highly invasive nature, tumor heterogeneity, stubborn immunosuppressive microenvironment, and the barrier effect of the blood-brain barrier result in limited efficacy of traditional surgery, radiotherapy, and chemotherapy, leading to high recurrence rates and short survival times