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Studies have shown that α-PVP and mephedrone significantly increase microglial activation in the striatum, contributing to long-term neurodegeneration ( 5 Ketamine Ketamine, first synthesized in the 1960s as a safer alternative to phencyclidine for anesthesia, has gained widespread use as both a therapeutic agent and recreational drug

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Ethics statement The studies involving human participants were reviewed and approved by CAMH Research Ethics Board