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The review traced foundational work demonstrating that protein glutathionylation occurs in response to both oxidative stress and hormonal stimulation, confirming it as a major mechanism of redox-regulated signal transduction

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30 , 31 The administration of NSAIDs is particularly concerning because, although they effectively mitigate pain associated with severe cases of OA, their use is known to be associated with potentially serious dose-dependent gastrointestinal (GI) complications, such as upper GI bleeding