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In animal models, intra-articular administration of liraglutide reduced the secretion of inflammatory cytokines such as IL-6, the expression of inflammatory genes in chondrocytes, the amount of proinflammatory M1 macrophages, and improved pain-related behaviors 104

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The GHK tag has limitations as it is restricted to just one tag at the N-terminus of a protein and is limited to the use of buffers that do not contain chelators such as imidazole or EDTA