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The two most common growth patterns of oral melanoma are (i) a superficial spreading radial growth pattern , featuring pagetoid spread with large melanoma cells in the superficial epithelium, and (ii) a less common but highly aggressive nodular growth pattern that often infiltrates deeply into the skin and presents as a dark, raised bump [45]

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Representation of an aged and senescent ECM, showing a reduction and fragmentation of elastin fibers, a lower amount of collagen fibers, the presence of senescence-associated fibroblasts, and the dispersion of molecules synthesized and released into the extracellular matrix by the senescence-associated secretory phenotype (SASP)