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Normally, the kelch-like erythroid-cell-derived protein with CNC homology (ECH)-Associated protein-1-Nrf2-(Keap-1-Nrf2-ARE) signaling pathway elicits an adaptive response for cell survival under OS, but they did not appear to operate effectively in periodontitis patients.[99] Therapeutic considerations of glutathione Glutathione supplementation may help to prevent or treat many conditions associated with impaired immune function due to elevated OS or aging [Table 6].[117] It has been postulated that raising glutathione levels in cells have reduced cancer growth by suppressing the activity of certain chemically-reactive oxygen molecules in the test tubes
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This is accompanied by mitochondrial dysfunction, oxidative stress, and neuroinflammation, ultimately triggering neuronal decline (Li et al., 2024c)