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These results would also be similar to outcomes from giving NAC before or shortly after APAP dosing, but by maintaining GSH levels to detoxify NAPQI, rather than preventing NAPQI formation

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Once activated, these receptors initiate intracellular signaling cascades , such as the PI3K-Akt pathway, which are critical for muscle protein synthesis, cellular growth, and survival (Jones & Clemmons, Endocrine Reviews )