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Sources Novo Nordisk: REDEFINE 4 headline results ClinicalTrials.gov: REDEFINE 4 (NCT06131437) REDEFINE 1 phase 3 trial ClinicalTrials.gov: REDEFINE 1 (NCT05567796) FDA prescribing information: Zepbound (2026) FDA: Concerns with unapproved GLP-1 drugs used for weight loss Novo Nordisk Science Hub: REDEFINE 1 treatment-target analysis 2026 systematic review and GRADE assessment of CagriSema trials This article is educational and does not provide individualized medical advice